Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Cell Cycle. 2010 Oct 15;9(20):4091-7. doi: 10.4161/cc.9.20.13587. Epub 2010 Oct 11.
F-BAR domain proteins serve as transient linkers between the cell cortex and the cytoskeleton in multiple biological contexts. Recent studies have detailed roles for this protein family in endocytosis, cytokinesis, neurotransmission, motility and cellular morphogenesis. Here, we review emerging functional information regarding the recently recognized F-BAR domain family and the regulatory mechanisms whereby F-BAR proteins are deployed in diverse processes.
F-BAR 结构域蛋白在多种生物学背景下充当细胞皮质和细胞骨架之间的瞬时连接物。最近的研究详细阐述了该蛋白家族在胞吞作用、胞质分裂、神经递质传递、运动和细胞形态发生中的作用。在这里，我们回顾了最近发现的 F-BAR 结构域家族的功能信息以及 F-BAR 蛋白在不同过程中被部署的调节机制。
