Weigmann Benno, Neurath Markus F
Department of Medicine 1, University of Erlangen-Nuremberg, Campus for Medical Research, Hartmannstr. 14, 91052, Erlangen, Germany.
Methods Mol Biol. 2016;1422:253-61. doi: 10.1007/978-1-4939-3603-8_23.
Murine models of intestinal inflammation have been widely used in biomedical research. Similarities in anatomy and physiology between such murine models and patients with inflammatory bowel diseases may allow a better understanding of the pathogenesis of Crohn's disease and ulcerative colitis. Additionally, models of intestinal inflammation may be used for the analysis of potentially new therapeutic agents. One key class of models consists of chemically induced inflammation models. Within this group, colitis induced by the haptenizing agent oxazolone is an important model that results in induction of acute or chronic inflammation of the large bowel. Here, we describe the induction and the analysis of this experimental colitis model.
肠道炎症的小鼠模型已广泛应用于生物医学研究。此类小鼠模型与炎症性肠病患者在解剖学和生理学上的相似性，可能有助于更好地理解克罗恩病和溃疡性结肠炎的发病机制。此外，肠道炎症模型可用于分析潜在的新型治疗药物。一类关键的模型包括化学诱导炎症模型。在这一组模型中，由半抗原化剂恶唑酮诱导的结肠炎是一个重要的模型，可导致大肠急性或慢性炎症的发生。在此，我们描述该实验性结肠炎模型的诱导和分析过程。
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