含结核分枝杆菌液泡的来龙去脉。
The ins and outs of the Mycobacterium tuberculosis-containing vacuole.
作者信息
Russell David G
机构信息
Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA.
出版信息
Cell Microbiol. 2016 Aug;18(8):1065-9. doi: 10.1111/cmi.12623. Epub 2016 Jun 27.
Abstract
The past few years have seen publication of reports from several groups documenting the escape of Mycobacterium tuberculosis (Mtb) from its intracellular vacuole to access the cytosol. The major questions addressed in these publications are the mechanism(s) underlying this process, the frequency of its occurrence and, most importantly, the biological significance of this phenomenon to bacterial survival, growth and virulence. I believe that the first two questions are moving towards resolution, but questions relating to biological context have yet to be answered fully. In this viewpoint article, I will try to convince the readers why escape from the vacuole in no way diminishes the significance of Mtb's intravacuolar survival mechanisms and why, as a lab, we continue to focus the majority of our efforts on the 'bug in the bag'.
摘要
在过去几年中，有几个研究小组发表了报告，记录了结核分枝杆菌（Mtb）从其细胞内液泡逃逸至胞质溶胶的情况。这些出版物中探讨的主要问题是这一过程背后的机制、其发生频率，以及最重要的是，这一现象对细菌生存、生长和毒力的生物学意义。我认为前两个问题正朝着解决的方向发展，但与生物学背景相关的问题尚未得到充分解答。在这篇观点文章中，我将试图说服读者，为什么从液泡中逃逸丝毫不会降低Mtb在液泡内存活机制的重要性，以及为什么作为一个实验室，我们仍将大部分精力集中在“包中的细菌”上。
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