Porter Adam, Rozanski Elizabeth, Price Lori Lyn, Shaw Scott
New England Veterinary Center and Cancer Care, 955 Kennedy Road, Windsor, Connecticut 06095, USA (Porter); Cummings School of Veterinary Medicine - Clinical Sciences, North Grafton, Massachusetts, USA (Rozanski); Tufts Medical Center, Boston, Massachusetts, USA (Price); VCA, Oxford, Massachusetts, USA (Shaw).
Can Vet J. 2016 Jun;57(6):641-5.
We used a point-of-care assay to evaluate cardiac troponin I (cTnI) in clinically normal dogs and a heterogeneous population of dogs presenting to the emergency room (ER) and to determine whether cTnI has prognostic capabilities in an ER population. Fourteen clinically normal dogs and 129 dogs presented to the ER were evaluated. Of the study group, 88 dogs had normal cTnI (< 0.1 ng/mL), 29 had elevated cTnI (0.1 to 1.0 ng/mL), and 12 had high cTnI (> 1.0 ng/mL). Dogs with elevated cTnI had 8 times the odds of mortality compared to dogs with normal cTnI [odds ratio (OR): 8.2, 95% confidence interval (CI): 3.0, 22.3]. Dogs with high cTnI had 17 times higher odds of mortality compared to dogs with normal cTnI (OR: 17.6, 95% CI: 4.4, 70.1). We conclude that cTnI shows promise as a prognostic indicator for dogs presenting to the ER and can be easily evaluated using a point-of-care assay.
我们使用即时检测法对临床正常犬以及到急诊室就诊的异质犬群进行心肌肌钙蛋白I(cTnI)评估,以确定cTnI在急诊犬群中是否具有预后评估能力。对14只临床正常犬和129只到急诊室就诊的犬进行了评估。在研究组中,88只犬的cTnI正常(<0.1 ng/mL),29只犬的cTnI升高(0.1至1.0 ng/mL),12只犬的cTnI很高(>1.0 ng/mL)。与cTnI正常的犬相比,cTnI升高的犬死亡几率高出8倍[比值比(OR):8.2,95%置信区间(CI):3.0,22.3]。与cTnI正常的犬相比,cTnI很高的犬死亡几率高出17倍(OR:17.6,95%CI:4.4,70.1)。我们得出结论,cTnI有望作为到急诊室就诊犬的预后指标,并且可以使用即时检测法轻松进行评估。