Hein J, Brock J
Kinderarztl Prax. 1989 Mar;57(3):133-40.
Investigations of immunoglobulin concentrations--especially of secretory IgA (sIgA)--were performed in isolated parotid saliva samples by means of a modified Mancini technique considering the structural specialties of sIgA. The measurement of flow rates under continuous stimulation of parotid gland secretion by citric acid allowed calculations of glandular output. Cystic fibrosis patients showed decreased secretion rates of sIgA during gland secretion stimulation. Because parotid glands and bronchial glands are parts of BALT, we can conclude, that a functional sIgA deficiency is a pathogenetic factor under others in chronic bronchopulmonary infections of cystic fibrosis patients.
通过改良的 Mancini 技术，考虑到分泌型 IgA（sIgA）的结构特点，对分离的腮腺唾液样本中的免疫球蛋白浓度，尤其是 sIgA 进行了研究。通过柠檬酸持续刺激腮腺分泌来测量流速，从而计算腺体输出量。囊性纤维化患者在腺体分泌刺激期间 sIgA 的分泌率降低。由于腮腺和支气管腺是支气管相关淋巴组织的一部分，我们可以得出结论，功能性 sIgA 缺乏是囊性纤维化患者慢性支气管肺部感染中诸多致病因素之一。
