Meyer R J, Cuttner J, Truog P, Ambinder E P, Holland J F
Med Pediatr Oncol. 1978;4(1):77-83. doi: 10.1002/mpo.2950040112.
Cytopheresis techniques have proven useful in the provision of platelets and granulocytes for transfusion to the pancytopenic patient. Mechanical cell removal has been applied to the treatment of chronic myelocytic and lymphocytic leukemias and the Sezary syndrome. We have treated a 16-year-old pregnant acute myelomonocytic leukemia (AMML) patient for 12 weeks solely with the use of intensive leukopheresis utilizing batch processing centrifugation and packed red cell transfusions. The patient presented with a white blood cell count of 54,000/mm3 with 64% myelomonoblasts, a platelet count of 45,000/mm3, marked gingival hyperplasia, and splenomegaly. Patient had a normal spontaneous delivery of a 2.5-kg male infant without complications. At the time of delivery, 12 weeks later, the white blood count had fallen to 4,9000/mm3 with 8% blasts and the platelet count had risen to over 100,000/mm3. Gingival hyperplasia decreased and the patient felt well. We have treated an additional small group of patients with acute myelogenous leukemia (AML) with high white counts with short term intensive leukopheresis followed by chemotherapy with promising results.
血细胞分离技术已被证明在为全血细胞减少症患者提供用于输血的血小板和粒细胞方面很有用。机械性细胞去除已应用于慢性粒细胞性和淋巴细胞性白血病以及塞扎里综合征的治疗。我们仅使用分批处理离心法进行强化白细胞去除术和输注浓缩红细胞，对一名16岁的急性粒单核细胞白血病（AMML）孕妇进行了为期12周的治疗。该患者就诊时白细胞计数为54,000/mm³，其中髓单核细胞占64%，血小板计数为45,000/mm³，有明显的牙龈增生和脾肿大。患者顺产一名2.5千克男婴，无并发症。12周后的分娩时，白细胞计数降至4,900/mm³，原始细胞占8%，血小板计数升至超过100,000/mm³。牙龈增生减轻，患者感觉良好。我们还用短期强化白细胞去除术治疗了另一小群白细胞计数高的急性髓性白血病（AML）患者，随后进行化疗，取得了有希望的结果。
