El Tahry Riëm, Hirsch Martin, Van Rijckevorsel Kenou, Santos Susana Ferrao, de Tourtchaninoff Marianne, Rooijakkers Herbert, Coenen Volker, Schulze-Bonhage Andreas
Department of Neurology, Centre for Refractory Epilepsy, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Epilepsy Centre, Medical Center - University of Freiburg, Faculty of Medecine, Freiburg, Germany.
Epileptic Disord. 2016 Jun 1;18(2):155-62. doi: 10.1684/epd.2016.0831.
Many epilepsy patients treated with vagus nerve stimulation additionally use an "on-demand" function, triggering an extra stimulation to terminate a seizure or diminish its severity. Nevertheless, a substantial number of patients are not able to actively trigger stimulations by use of a magnet, due to the absence of an aura or inability for voluntary actions in the early phase of a seizure. To address this need, a novel implantable pulse generator, the AspireSR VNS system, was developed to provide automated ictal stimulation triggered by a seizure-detecting algorithm. We report our experience with three patients in assessing the functionality of ictal stimulation, illustrating the detection system in practice. Detection of ictal tachycardia and variable additional detections of physiological tachycardia depended on the individual seizure-detecting algorithm settings.
许多接受迷走神经刺激治疗的癫痫患者还会使用“按需”功能，触发额外刺激以终止癫痫发作或减轻其严重程度。然而，相当一部分患者由于在癫痫发作早期没有先兆或无法自主行动，无法通过使用磁铁主动触发刺激。为满足这一需求，研发了一种新型植入式脉冲发生器——AspireSR VNS系统，以提供由癫痫检测算法触发的自动发作期刺激。我们报告了对三名患者评估发作期刺激功能的经验，展示了实际中的检测系统。发作期心动过速的检测以及生理性心动过速的可变额外检测取决于个体癫痫检测算法的设置。
