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One step at a time: CYP2D6 guided tamoxifen treatment awaits convincing evidence of clinical validity.

作者信息

Hertz Daniel L, Rae James M

机构信息

Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA.

Division of Hematology/Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.

出版信息

Pharmacogenomics. 2016 Jun;17(8):823-6. doi: 10.2217/pgs-2016-0059. Epub 2016 Jun 1.

DOI:10.2217/pgs-2016-0059
PMID:27249031
Abstract
摘要

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引用本文的文献

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J Pers Med. 2022 Mar 22;12(4):511. doi: 10.3390/jpm12040511.
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Tamoxifen side effects: pharmacogenetic and clinical approach in Mexican mestizos.他莫昔芬的副作用:墨西哥混血人种的药物遗传学及临床研究方法
Transl Cancer Res. 2019 Feb;8(1):23-34. doi: 10.21037/tcr.2018.12.27.
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Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen.
低 Z-4OHtam 浓度与接受辅助他莫昔芬治疗的早期绝经前乳腺癌患者不良临床结局相关。
Mol Oncol. 2021 Apr;15(4):957-967. doi: 10.1002/1878-0261.12865. Epub 2020 Dec 14.
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CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Prognosis in Patients With Breast Cancer.CYP2D6 基因型预测乳腺癌患者他莫昔芬停药和预后。
J Clin Oncol. 2020 Feb 20;38(6):548-557. doi: 10.1200/JCO.19.01535. Epub 2019 Dec 4.
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Clin Drug Investig. 2020 Jan;40(1):25-32. doi: 10.1007/s40261-019-00842-0.
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Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen.通过CYP2D6基因型改善对接受他莫昔芬治疗的乳腺癌患者中内昔芬代谢的预测
Front Pharmacol. 2017 Aug 24;8:582. doi: 10.3389/fphar.2017.00582. eCollection 2017.
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CYP2D6 genotype is not associated with survival in breast cancer patients treated with tamoxifen: results from a population-based study.CYP2D6 基因型与接受他莫昔芬治疗的乳腺癌患者的生存无关:一项基于人群的研究结果。
Breast Cancer Res Treat. 2017 Nov;166(1):277-287. doi: 10.1007/s10549-017-4400-8. Epub 2017 Jul 20.
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Limited influence of germline genetic variation on all-cause mortality in women with early onset breast cancer: evidence from gene-based tests, single-marker regression, and whole-genome prediction.种系基因变异对早发性乳腺癌女性全因死亡率的影响有限:基于基因检测、单标记回归和全基因组预测的证据
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