Taylor N S, Ellenberger M A, Wu P Y, Fox J G
Lab Anim Sci. 1989 May;39(3):219-21.
One hundred nineteen isolates of Campylobacter jejuni and Campylobacter coli from nine laboratory animal species were serotyped using antisera to 20 Penner serotypes commonly isolated from cases of human enteric infections. Although C. jejuni and C. coli were isolated from laboratory animals with diarrhea, the majority were cultured from asymptomatic animals (81%). Seven of twenty-two isolates from animals with diarrhea were serotype 4 (32%) and three were serotype 1 (14%). Sixty-one of the 119 isolates (51%) were typeable using the 20 Penner antisera indicating that many of the isolates obtained from 29 nonhuman primates (five species), 20 ferrets, 7 hamsters, 15 cats and 48 dogs are serotypes commonly associated with human enteritis. Among typeable strains, 13 different serotypes were identified. Two particular serotypes, 4 and 19 were isolated from several species of animals and comprised 24% of the isolates studied. Since asymptomatic laboratory animals of several different species harbor serotypes of C. jejuni and C. coli that are potentially pathogenic to man, appropriate precautions should be instituted to minimize exposure of personnel to the organisms in laboratory animal feces. If suspected cases of zoonotic-related enteric campylobacteriosis involving laboratory animals do occur, serotyping of isolates would be a useful epidemiologic marker in studying the outbreak.
使用针对20种从人类肠道感染病例中常见分离出的Penner血清型的抗血清，对来自9种实验动物的119株空肠弯曲菌和结肠弯曲菌进行了血清分型。虽然空肠弯曲菌和结肠弯曲菌是从患有腹泻的实验动物中分离出来的，但大多数是从无症状动物中培养出来的（81%）。从腹泻动物中分离出的22株菌株中有7株为血清型4（32%），3株为血清型1（14%）。119株分离株中有61株（51%）可使用20种Penner抗血清进行分型，这表明从29只非人灵长类动物（5个物种）、20只雪貂、7只仓鼠、15只猫和48只狗中获得的许多分离株是与人类肠炎常见相关的血清型。在可分型菌株中，鉴定出13种不同的血清型。两种特定的血清型，4型和19型，从几种动物中分离出来，占所研究分离株的24%。由于几种不同物种的无症状实验动物携带对人类有潜在致病性的空肠弯曲菌和结肠弯曲菌血清型，应采取适当的预防措施，以尽量减少人员接触实验动物粪便中的微生物。如果确实发生了涉及实验动物的人畜共患相关肠道弯曲菌病疑似病例，分离株的血清分型将是研究疫情爆发的有用流行病学标志物。
