Haverkampf Sonja, Heider Judith, Weiß Katharina T, Haubner Frank, Ettl Tobias, Schreml Julia, Hedtrich Sarah, von Süßkind-Schwendi Marietta, Berneburg Mark, Karrer Sigrid, Dissemond Joachim, Schreml Stephan
Department of Dermatology, University Medical Center Regensburg, Regensburg, Germany.
Department of Otorhinolaryngology, University Medical Center Regensburg, Regensburg, Germany.
Exp Dermatol. 2017 Feb;26(2):124-126. doi: 10.1111/exd.13097. Epub 2017 Jan 9.
Wound repair is an orchestrated process, encompassing the phases of inflammation, proliferation and tissue remodeling. In this context, sodium hydrogen exchanger 1 (NHE1) is crucial to epidermal barrier integrity and acidification. Recently, we found that extracellular pH (pHe) on wound surfaces is dramatically increased initially after barrier disruption, and that pHe decreases gradually during physiological healing. Additionally, we have shown that spatial NHE1-patterns account for pHe-gradients on surfaces of chronic wounds. Here, we show that NHE1-expression is very low at margins initially after wounding and that it increases massively during the time-course of physiolgical healing. This finding is in accordance with the decrease of pHe on wound surfaces, which we reported on in previous works. Thus, we show that NHE1 is an interesting target when it comes to modification of surface pHe on wounds, both acute and chronic, and that NHE1 is time-dependently regulated in physiological healing.
伤口修复是一个精心编排的过程，包括炎症、增殖和组织重塑阶段。在这种情况下，钠氢交换体1（NHE1）对于表皮屏障的完整性和酸化至关重要。最近，我们发现屏障破坏后伤口表面的细胞外pH（pHe）最初会急剧升高，并且在生理愈合过程中pHe会逐渐降低。此外，我们已经表明，空间NHE1模式解释了慢性伤口表面的pHe梯度。在这里，我们表明受伤后最初边缘处的NHE1表达非常低，并且在生理愈合过程中会大量增加。这一发现与我们之前报道的伤口表面pHe的降低一致。因此，我们表明，在改变急性和慢性伤口的表面pHe方面，NHE1是一个有趣的靶点，并且NHE1在生理愈合中受到时间依赖性调节。
