Robinson Giles W, Witt Hendrik, Resnick Adam
From the Division of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN; Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany; Center for Data Driven Discovery in Biomedicine, Division of Neurosurgery, The Children's Hospital of Philadelphia, Philadelphia, PA.
Am Soc Clin Oncol Educ Book. 2016;35:e540-6. doi: 10.1200/EDBK_159149.
Over a relatively short period of time, owing to improvements in biotechnology, our ability to identify the molecular mechanisms within pediatric brain tumors has dramatically increased. These findings have reshaped the way that we describe these diseases and have provided insights into how to better treat these often devastating diseases. Although still far from reaching the full therapeutic potential these advancements hold, the impact of these findings is steadily taking hold of pediatric brain tumor management. In this article, we summarize the major discoveries within three common pediatric brain tumor categories; medulloblastoma, ependymoma, and low-grade glioma. We discuss the current impact of these findings on treatment and the direction these findings may take the field of pediatric neuro-oncology.
在相对较短的时间内，由于生物技术的进步，我们识别小儿脑肿瘤分子机制的能力有了显著提高。这些发现重塑了我们描述这些疾病的方式，并为如何更好地治疗这些通常具有毁灭性的疾病提供了见解。尽管距离充分发挥这些进展所蕴含的治疗潜力仍有很大差距，但这些发现的影响正稳步在小儿脑肿瘤管理中发挥作用。在本文中，我们总结了三种常见小儿脑肿瘤类型（髓母细胞瘤、室管膜瘤和低级别胶质瘤）的主要发现。我们讨论了这些发现目前对治疗的影响以及这些发现可能引领小儿神经肿瘤学领域发展的方向。
