Vanderzant C W, Schott R J, Natale J E, Pondo C A, D'Alecy L G
Department of Neurology, University of Michigan Medical School, Ann Arbor 48109-0036.
J Neurosci Methods. 1989 Apr;27(3):253-63. doi: 10.1016/0165-0270(89)90087-3.
Median and tibial nerve somatosensory evoked potentials (SSEPs) of 5 sedated dogs were studied to determine their normal features and optimal stimulation and recording techniques. Cortical potentials were mapped from an extensive array of skull electrodes as each limb was independently stimulated with subdermal needles. The effects of bandpass and stimulus intensity and rate were also assessed. Three cortical components (P1, N1, P2) were evoked by median or tibial nerve stimulation and were localized along the coronal suture at lateral and medial electrodes, respectively. SSEP voltage varied much more than morphology, topography, or latency. The inion was a stable, indifferent reference site. Cortical SSEP frequency content was mostly below 250 Hz. Maximal SSEP voltage was achieved only at stimulus intensities 2-3 times motor threshold. Appropriate methods minimize technical difficulties and consistently yield legible SSEPs.
对5只镇静犬的正中神经和胫神经体感诱发电位（SSEP）进行了研究，以确定其正常特征以及最佳刺激和记录技术。当用皮下针独立刺激每个肢体时，从大量颅骨电极记录皮层电位。还评估了带通、刺激强度和频率的影响。正中神经或胫神经刺激可诱发三个皮层成分（P1、N1、P2），分别位于外侧和内侧电极沿冠状缝的位置。SSEP电压的变化远大于形态、地形图或潜伏期。枕外隆凸是一个稳定的无关参考点。皮层SSEP频率成分大多低于250Hz。仅在刺激强度为运动阈值的2至3倍时才能获得最大SSEP电压。适当的方法可将技术难题降至最低，并始终产生清晰可读的SSEP。
