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Editorial: "Invisible" MDSC in tumor-bearing individuals after antibody depletion: fact or fiction?

作者信息

Ma Chi, Greten Tim F

机构信息

Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Gastrointestinal Malignancy Section, Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

出版信息

J Leukoc Biol. 2016 Jun;99(6):794. doi: 10.1189/jlb.5CE0116-047R.

DOI:10.1189/jlb.5CE0116-047R
PMID:27252522
Abstract
摘要

相似文献

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Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice.使用Ly6G特异性单克隆抗体清除小鼠体内的中性粒细胞。
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Treatment of mice with the neutrophil-depleting antibody RB6-8C5 results in early development of experimental lyme arthritis via the recruitment of Gr-1- polymorphonuclear leukocyte-like cells.用中性粒细胞耗竭抗体RB6-8C5治疗小鼠,会通过募集Gr-1 - 多形核白细胞样细胞导致实验性莱姆关节炎的早期发展。
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Depletion of Gr-1+, but not Ly6G+, immune cells exacerbates virus replication and disease in an intranasal model of herpes simplex virus type 1 infection.耗竭 Gr-1+,但不耗竭 Ly6G+免疫细胞,会加重鼻内感染单纯疱疹病毒 1 型模型中的病毒复制和疾病。
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Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression.中性粒细胞浸润是良性小鼠纤维肉瘤细胞获得转移表型所必需的:对炎症相关致癌作用和肿瘤进展的启示。
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Neutrophils from Mycobacterium avium-infected mice produce TNF-alpha, IL-12, and IL-1 beta and have a putative role in early host response.来自鸟分枝杆菌感染小鼠的中性粒细胞会产生肿瘤坏死因子-α、白细胞介素-12和白细胞介素-1β,并且在早期宿主反应中可能发挥作用。
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Anti-Gr-1 Antibody Provides Short-Term Depletion of MDSC in Lymphodepleted Mice with Active-Specific Melanoma Therapy.抗Gr-1抗体在接受主动特异性黑色素瘤治疗的淋巴细胞清除小鼠中可实现髓源性抑制细胞的短期清除。
Vaccines (Basel). 2022 Apr 4;10(4):560. doi: 10.3390/vaccines10040560.
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Reprogramming the lung microenvironment by inhaled immunotherapy fosters immune destruction of tumor.通过吸入式免疫疗法对肺微环境进行重编程可促进肿瘤的免疫破坏。
Oncoimmunology. 2016 Sep 20;5(11):e1234571. doi: 10.1080/2162402X.2016.1234571. eCollection 2016.