头孢洛扎/他唑巴坦在一名小儿白血病患者多重耐药铜绿假单胞菌血流感染治疗中的应用
Use of Ceftolozane/Tazobactam in the Treatment of Multidrug-resistant Pseudomonas aeruginosa Bloodstream Infection in a Pediatric Leukemia Patient.
作者信息
Aitken Samuel L, Kontoyiannis Dimitrios P, DePombo April M, Bhatti Micah M, Tverdek Frank P, Gettys Suzanne C, Nicolau David P, Nunez Cesar A
机构信息
From the *Division of Pharmacy, †Department of Infectious Diseases, Infection Control, and Employee Health, ‡Department of Laboratory Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas; §Center for Anti-infective Research and Development, Hartford Hospital, Hartford, Connecticut; and ¶Department of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, Texas.
出版信息
Pediatr Infect Dis J. 2016 Sep;35(9):1040-2. doi: 10.1097/INF.0000000000001228.
Multidrug-resistant Pseudomonas aeruginosa is of increasing concern in pediatric patients. Ceftolozane/tazobactam is a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant Pseudomonas; however, no data exist on its use in children. This report summarizes the treatment of a multidrug-resistant P. aeruginosa bloodstream infection in a pediatric leukemia patient with ceftolozane/tazobactam and provides the first description of its pharmacokinetics in pediatrics.
多重耐药铜绿假单胞菌在儿科患者中越来越受到关注。头孢洛扎/他唑巴坦是一种新型头孢菌素/β-内酰胺酶抑制剂组合，对多重耐药铜绿假单胞菌具有活性；然而，尚无其在儿童中使用的数据。本报告总结了一名儿科白血病患者使用头孢洛扎/他唑巴坦治疗多重耐药铜绿假单胞菌血流感染的情况，并首次描述了其在儿科患者中的药代动力学。
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