Infectious Diseases Department, Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain.
Microbiology Department, Hospital Clínic-ISGLOBAL; University of Barcelona, Barcelona, Spain.
Future Microbiol. 2017 Nov;12:1323-1326. doi: 10.2217/fmb-2017-0018. Epub 2017 Oct 5.
Ceftolozane/tazobactam is a novel fifth-generation cephalosporin β-lactamase combination with activity against extended-spectrum β-lactamases-producing enterobacteriaceae, and multidrug resistant Pseudomonas aeruginosa. However, clinical experience in real cases caused by these microorganisms is scarce. In this study, we describe three patients with severe infections caused by multidrug resistant and extensively drug-resistant (XDR) P. aeruginosa that were successfully treated with ceftolozane/tazobactam.
头孢洛扎他唑巴坦是一种新型第五代头孢菌素β-内酰胺酶抑制剂复合制剂，对产超广谱β-内酰胺酶的肠杆菌科和多重耐药铜绿假单胞菌具有活性。然而，针对这些微生物引起的真实病例的临床经验还很有限。在本研究中，我们描述了 3 例由多重耐药和广泛耐药（XDR）铜绿假单胞菌引起的严重感染患者，他们使用头孢洛扎他唑巴坦治疗获得了成功。
