Schilling L, Wahl M
Physiologisches Institut, Universität München, BRD.
Miner Electrolyte Metab. 1989;15(3):178-84.
The effects of nimodipine on feline pial arteries were studied before and after cortical spreading depression (CSD) using perivascular microapplication. Vessel diameter was measured by image splitting technique. Nimodipine was used as liposome suspension. Before CSD nimodipine induced a dilatation of 23.3 +/- 2.7% (mean +/- SEM) at 2.4 x 10(-7) M, while the empty liposomes elicited a nonsignificant constriction of 1.3%. After CSD the nimodipine-induced dilatation was significantly diminished to an average of 15%. This attenuated response to nimodipine is discussed and thought to be due to a more general decrease in cerebrovascular reactivity after CSD.
使用血管周围微量给药法，研究了皮质扩散性抑制（CSD）前后尼莫地平对猫软脑膜动脉的影响。通过图像分割技术测量血管直径。尼莫地平以脂质体悬浮液的形式使用。在CSD之前，2.4×10⁻⁷M的尼莫地平可引起23.3±2.7%（平均值±标准误）的扩张，而空脂质体引起的收缩不显著，为1.3%。CSD后，尼莫地平诱导的扩张显著减弱至平均15%。本文讨论了对尼莫地平反应减弱的情况，并认为这是由于CSD后脑血管反应性更普遍降低所致。
