Smith R F, Mattran K M, Kurkjian M F, Kurtz S L
Department of Psychology, George Mason University, Fairfax, VA 22030.
Neurotoxicol Teratol. 1989 Jan-Feb;11(1):35-8. doi: 10.1016/0892-0362(89)90082-2.
Sperm-positive female Long-Evans hooded rats were dosed subcutaneously with 10 mg/kg/day cocaine or an equal volume of vehicle (0.9% sterile saline) from gestation day 4 (GD4) through GD18. Offspring were assessed for development of negative geotaxis, righting reflex, spontaneous alternation, and open field activity, and for adult behaviors including DRL-20 acquisition, water maze, visual discrimination, barbiturate sleep time, shuttlebox avoidance, footshock sensitivity, and tail flick latency. Cocaine dosing produced no significant effects on dam weight gain, any measure of litter size and weight, or early postnatal behavioral tests, but there were significant drug effects on development of spontaneous alternation, development of open field activity, DRL-20 acquisition, water maze performance, tail flick, and footshock sensitivity. These data suggest that chronic administration of a modest dose of cocaine during gestation in the rat alters a number of behaviors in the offspring.
从妊娠第4天（GD4）至GD18，对精子阳性的雌性Long-Evans Hooded大鼠皮下注射10毫克/千克/天的可卡因或等体积的赋形剂（0.9%无菌生理盐水）。对后代进行负趋地性、翻正反射、自发交替和旷场活动发育的评估，以及对包括DRL-20习得、水迷宫、视觉辨别、巴比妥睡眠时间、穿梭箱回避、足底电击敏感性和甩尾潜伏期在内的成年行为的评估。可卡因给药对母鼠体重增加、任何窝仔大小和体重指标或产后早期行为测试均无显著影响，但对自发交替发育、旷场活动发育、DRL-20习得、水迷宫表现、甩尾和足底电击敏感性有显著药物影响。这些数据表明，大鼠妊娠期慢性给予适度剂量的可卡因会改变后代的多种行为。
