美国阿肯色州马绍尔人群中的结核病和麻风病感染情况。

Tuberculosis and leprosy infections in the Marshallese population of Arkansas, USA.

作者信息

Cardenas Victor Manuel, Orloff Mohammed S, Kaminaga Joseph, Cardenas Irma Carrillo, Brown Joeline, Hainline-Williams Sandra, Duthie Malcolm S, Gonzalez-Puche Angela C, Mukasa Leonard, Patil Naveen, Mcelfish Pearl Ann, Bates Joseph H

出版信息

Lepr Rev. 2016 Mar;87(1):109-12.

PMID:27255065

Abstract

The cross-immunity between tuberculosis and leprosy is unknown. The aim of this pilot study was to evaluate the occurrence of Mycobacterium tuberculosis and M. leprae infection in Marshallese adult volunteers in Springdale, Arkansas, U.S.A., a population that experiences high rates of leprosy and tuberculosis. We used immunodiagnostic testing for tuberculosis and leprosy infection and found significant prevalence of latent tuberculosis infection (19.0%), and asymptomatic Mycobacterium leprae infection (22.2%). We found a negative association between presence of antibodies to Mycobacterium leprae and a positive interferon-γ release assay for Mycobacterium tuberculosis infection, prevalence odds ratio = 0.1 (95% CI = 0.0, 0.9). Although these findings require confirmation on a larger scale, they are supportive of the existence of cross-immunity.

摘要

结核病和麻风病之间的交叉免疫尚不清楚。这项初步研究的目的是评估美国阿肯色州斯普林代尔的马绍尔群岛成年志愿者中结核分枝杆菌和麻风分枝杆菌感染的发生情况，该人群中麻风病和结核病的发病率很高。我们使用了针对结核病和麻风病感染的免疫诊断测试，发现潜伏性结核感染的患病率很高（19.0%），以及无症状麻风分枝杆菌感染（22.2%）。我们发现，针对麻风分枝杆菌的抗体的存在与结核分枝杆菌感染的γ-干扰素释放试验呈阴性相关，患病率比值比 = 0.1（95%置信区间 = 0.0，0.9）。尽管这些发现需要在更大规模上得到证实，但它们支持交叉免疫的存在。