Pacy P J, Halliday D
Nutrition Research Group, Clinical Research Centre, Harrow, UK.
Muscle Nerve. 1989 May;12(5):378-81. doi: 10.1002/mus.880120507.
A 51-year-old man with proven adenosquamous carcinoma of the lung presented with clinically acute steroid myopathy. Postabsorptive whole body leucine kinetics and fractional mixed muscle protein synthesis rate (MPSR) were determined by a steady-state approach during continuous L-(1-13C) leucine infusion. Plasma 13C alpha-ketoisocaproic acid enrichment was taken to represent labeling of the precursor pool. Postabsorptive whole body leucine flux and protein synthesis were less than the 1 in 500 confidence intervals of control values. Fractional MPSR was significantly reduced (P less than 0.01). Simultaneous calculation of MPSR from two adjacent sites was in excellent agreement (0.0372 and 0.0395% h-1). This is the first report that steroid myopathy is associated with reduced whole body protein synthesis and fractional MPSR in man.
一名51岁经证实患有肺腺鳞癌的男性出现临床急性类固醇肌病。在持续输注L-(1-13C)亮氨酸期间，采用稳态法测定空腹全身亮氨酸动力学和混合肌肉蛋白合成率（MPSR）分数。血浆13Cα-酮异己酸富集度用于代表前体池的标记。空腹全身亮氨酸通量和蛋白质合成低于对照值的500分之一置信区间。MPSR分数显著降低（P<0.01）。从两个相邻部位同时计算的MPSR结果高度一致（分别为0.0372和0.0395% h-1）。这是关于类固醇肌病与人全身蛋白质合成减少和MPSR分数降低相关的首份报告。
