Rab32/38 和吞噬作用对内源性细菌复制的限制。
Rab32/38 and the xenophagic restriction of intracellular bacteria replication.
机构信息
Department of Biochemistry and NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore.
出版信息
Microbes Infect. 2016 Oct;18(10):595-603. doi: 10.1016/j.micinf.2016.05.006. Epub 2016 May 30.
Rab GTPases' subversion by intracellular pathogens during infection has been extensively documented. Recent findings have implicated a key intracellular bacterial restriction/containment function for Rab32/38 in Salmonella species in macrophages and Listeria monocytogenes in dendritic cells. Rab32/38 aids the phagolysosome maturation, and mediates a parallel xenophagy mechanism by engaging prohibitins.
Rab GTPases 的在感染过程中被细胞内病原体颠覆已被广泛记录。最近的研究结果表明 Rab32/38 在沙门氏菌属感染巨噬细胞和单核细胞增生李斯特菌感染树突状细胞中具有关键的细胞内细菌限制/包含功能。Rab32/38 有助于吞噬体成熟，并通过结合抑素来介导平行的异噬机制。
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