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A conjugate of acyclovir monophosphate with lactosaminated albumin releases the phosphorylated drug in liver cells.

作者信息

Fiume L, Busi C, Mattioli A, Spinelli C, Spinosa G, Bongini A

机构信息

Dipartimento di Patologia sperimentale, Bologna.

出版信息

Naturwissenschaften. 1989 Feb;76(2):74-6. doi: 10.1007/BF00396711.

DOI:10.1007/BF00396711
PMID:2725686
Abstract
摘要

相似文献

1
A conjugate of acyclovir monophosphate with lactosaminated albumin releases the phosphorylated drug in liver cells.单磷酸阿昔洛韦与乳糖胺化白蛋白的缀合物在肝细胞中释放磷酸化药物。
Naturwissenschaften. 1989 Feb;76(2):74-6. doi: 10.1007/BF00396711.
2
Adenine arabinoside monophosphate and acyclovir monophosphate coupled to lactosaminated albumin reduce woodchuck hepatitis virus viremia at doses lower than do the unconjugated drugs.
Hepatology. 1991 Jul;14(1):16-24. doi: 10.1002/hep.1840140104.
3
A conjugate of lactosaminated poly-L-lysine with adenine arabinoside monophosphate, administered to mice by intramuscular route, accomplishes a selective delivery of the drug to the liver.
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4
The pathogenesis of vacuoles produced in rat and mouse liver cells by a conjugate of adenine arabinoside monophosphate with lactosaminated albumin.单磷酸阿糖腺苷与乳糖胺化白蛋白结合物在大鼠和小鼠肝细胞中产生空泡的发病机制。
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5
Galactosylated poly(L-lysine) as a hepatotropic carrier of 9-beta-D-arabinofuranosyladenine 5'-monophosphate.半乳糖基化聚-L-赖氨酸作为5'-单磷酸9-β-D-阿拉伯呋喃糖基腺嘌呤的肝靶向载体。
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6
Drug targeting in antiviral chemotherapy. A chemically stable conjugate of 9-beta-D-arabinofuranosyl-adenine 5'-monophosphate with lactosaminated albumin accomplishes a selective delivery of the drug to liver cells.抗病毒化疗中的药物靶向作用。9-β-D-阿拉伯呋喃糖基腺嘌呤5'-单磷酸与乳糖胺化白蛋白的化学稳定缀合物实现了药物向肝细胞的选择性递送。
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7
Organ distribution of a conjugate of adenine arabinoside monophosphate with lactosaminated albumin in the rat.大鼠体内单磷酸阿糖腺苷与乳糖胺化白蛋白缀合物的器官分布
J Hepatol. 1994 May;20(5):681-2. doi: 10.1016/s0168-8278(05)80363-0.
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Lactosaminated human serum albumin as hepatotropic drug carrier. Rate of uptake by mouse liver.乳糖胺化人血清白蛋白作为肝脏靶向药物载体。小鼠肝脏的摄取率。
FEBS Lett. 1982 Sep 6;146(1):42-6. doi: 10.1016/0014-5793(82)80701-1.
9
[Study on liver targeted valaciclovir polybutylcyanoacrylate nanoparticles].
Yao Xue Xue Bao. 1998 Sep;33(9):702-6.
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Selective penetration and pharmacological activity of lactosaminated albumin conjugates of adenine arabinoside 5-monophosphate (ara-AMP) in mouse liver.5-单磷酸阿糖腺苷（ara-AMP）的乳糖胺化白蛋白缀合物在小鼠肝脏中的选择性渗透和药理活性。
Gut. 1984 Dec;25(12):1392-8. doi: 10.1136/gut.25.12.1392.

本文引用的文献

1
The metabolism of P32-labeled ribonucleotides in tissue slices and cell suspensions.P32标记的核糖核苷酸在组织切片和细胞悬液中的代谢
J Biol Chem. 1955 Oct;216(2):823-30.
2
Acyclovir in hepatitis B antigen-positive chronic liver disease: inhibition of viral replication and transient renal impairment with iv bolus administration.阿昔洛韦用于乙肝抗原阳性慢性肝病：静脉推注给药对病毒复制的抑制作用及短暂性肾功能损害
J Antimicrob Chemother. 1983 Mar;11(3):223-31. doi: 10.1093/jac/11.3.223.
3
Metabolism of arabinosyladenine in herpes simplex virus-infected and uninfected cells. Correlation with inhibition of DNA synthesis and role in antiviral selectivity.
单纯疱疹病毒感染和未感染细胞中阿糖腺苷的代谢。与DNA合成抑制的相关性及在抗病毒选择性中的作用。
Biochem Pharmacol. 1984 Aug 1;33(15):2431-8. doi: 10.1016/0006-2952(84)90715-9.
4
A novel method for phosphorylation of nucleosides to 5'-nucleotides.一种将核苷磷酸化为5'-核苷酸的新方法。
Tetrahedron Lett. 1967 Dec;50:5065-8. doi: 10.1016/s0040-4039(01)89915-9.
5
The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins.表面碳水化合物在肝脏对循环糖蛋白的识别和转运中的作用。
Adv Enzymol Relat Areas Mol Biol. 1974;41(0):99-128. doi: 10.1002/9780470122860.ch3.
6
Targeting of antiviral drugs bound to protein carriers.靶向与蛋白质载体结合的抗病毒药物。
Crit Rev Ther Drug Carrier Syst. 1988;4(4):265-84.
7
Antiviral chemotherapy and chemoprophylaxis.抗病毒化疗与化学预防。
Science. 1985 Mar 15;227(4692):1296-303. doi: 10.1126/science.2983421.
8
Conjugates of 9-beta-D-arabinofuranosyladenine 5'-monophosphate (ara-AMP) with lactosaminated albumin. Characterization of the drug-carrier bonds.9-β-D-阿拉伯呋喃糖基腺嘌呤5'-单磷酸酯（ara-AMP）与乳糖胺化白蛋白的缀合物。药物-载体键的表征。
Pharm Acta Helv. 1988;63(4-5):137-9.
9
Inhibition of hepatitis B virus replication by vidarabine monophosphate conjugated with lactosaminated serum albumin.乳糖胺化血清白蛋白偶联的单磷酸阿糖腺苷对乙型肝炎病毒复制的抑制作用
Lancet. 1988 Jul 2;2(8601):13-5. doi: 10.1016/s0140-6736(88)92946-7.
10
Conjugates of ara-AMP with lactosaminated albumin: a study on their immunogenicity in mouse and rat.阿糖腺苷单磷酸与乳糖胺化白蛋白的缀合物：对其在小鼠和大鼠体内免疫原性的研究
Cancer Drug Deliv. 1987;4(3):145-50. doi: 10.1089/cdd.1987.4.145.