γ-氨基丁酸拮抗剂二硫四氮金刚烷对海马脑片神经元诱发反应的影响
[Effect of the gamma-aminobutyric acid antagonist disulfotetraazaadamantane on the evoked responses of neurons in hippocampal slices].
作者信息
Pervukhin G Ia, Sharonova I N, Prokof'ev S E, Fedorov N B, Kotel'nikov S A
出版信息
Neirofiziologiia. 1989;21(1):66-70.
PMID:2725787
Abstract
DSTA was analyzed for its effect, on the amplitude of population spikes (PS) evoked in CA1 area by the Shaffer collateral stimulation in hippocampal slices. Bath application of DSTA (10(-6)-10(-5) mol/l) caused a pronounced increase in the amplitude of PS and appearance of secondary PS. Introduction of GABA restored it to the initial state. These results demonstrate that DSTA inhibits the synaptic transmission in the CA1 region of the hippocampus.
摘要
对二硫代氨基甲酸盐（DSTA）的作用进行了分析，研究其对海马切片中通过Schaffer侧支刺激在CA1区诱发的群体峰电位（PS）幅度的影响。浴槽中应用DSTA（10⁻⁶ - 10⁻⁵ mol/l）导致PS幅度显著增加并出现继发性PS。加入γ-氨基丁酸（GABA）后其恢复到初始状态。这些结果表明DSTA抑制海马CA1区的突触传递。
Zotero 插件