Effect of anticonvulsant drugs on alkaline phosphatase and gamma-glutamyltransferase activity in human leukocytes.

The authors compared the alkaline phosphatase and gamma-glutamyl-transferase activities in leukocytes from presumably healthy subjects and from epileptic patients treated with anticonvulsants, matched for age and sex. Intraleukocyte alkaline phosphatase activity was higher in women than in men and was greatly reduced by the anticonvulsant drugs. Intraleukocyte gammaglutamyltransferase activity did not vary with sex and was unaffected by the anticonvulsant drugs contrary to findings for the activity of this enzyme in plasma and liver.