自体干细胞移植后监测多发性骨髓瘤患者时血清蛋白电泳（SPE）、免疫固定电泳（IFE）和游离轻链（FLC）的比较

Comparison of SPE, IFE, and FLC in Monitoring Patients with Multiple Myeloma After Autologous Stem Cell Transplantation.

作者信息

Li Wei, Zhou Jia-Zi, Chang Hui-Rong, Dai Li-Jun, Zhu Zi-Ling, Feng Yu-Feng, Gong Fei-Ran, Wu De-Pei

机构信息

Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.

PREMED Key Laboratory for Precision Medicine, Soochow University, Suzhou, China.

出版信息

Cell Biochem Biophys. 2015 Dec;73(3):643-7. doi: 10.1007/s12013-015-0655-z.

DOI:10.1007/s12013-015-0655-z

PMID:27259306

Abstract

Conventionally, serum protein electrophoresis (SPE) and serum immunofixation electrophoresis (IFE) are used as primary methods to diagnose and monitor multiple myeloma (MM). Recently, serum-free light chain (FLC) assay has been incorporated into hematological screening programs for myeloma. The purpose of this study is to compare the performance of the three methods in monitoring MM patients after autologous stem cell transplantation (ASCT). SPE, serum IFE and serum FLC assay were performed on 38 MM patients who underwent ASCT. In total, four patients had unexpected protein bands (UPBs) and 13 patients had relapsed after ASCT. Our results indicate that IFE is more sensitive than SPE and FLC assay in detection of UPBs and relapse. The results of IFE may provide useful information in advance of patient relapse.

摘要

传统上，血清蛋白电泳（SPE）和血清免疫固定电泳（IFE）被用作诊断和监测多发性骨髓瘤（MM）的主要方法。最近，游离轻链（FLC）检测已被纳入骨髓瘤的血液学筛查项目。本研究的目的是比较这三种方法在监测自体干细胞移植（ASCT）后MM患者中的性能。对38例接受ASCT的MM患者进行了SPE、血清IFE和血清FLC检测。总共有4例患者出现意外蛋白条带（UPB），13例患者在ASCT后复发。我们的结果表明，IFE在检测UPB和复发方面比SPE和FLC检测更敏感。IFE的结果可能在患者复发前提供有用信息。