Kobayashi Katsuhiro, Akiyama Tomoyuki, Oka Makio, Endoh Fumika, Yoshinaga Harumi
Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.
Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Okayama, Japan.
Brain Dev. 2016 Nov;38(10):909-914. doi: 10.1016/j.braindev.2016.05.005. Epub 2016 May 31.
To elucidate the generative mechanisms of epileptic spasms (ESs) in West syndrome, we investigated the temporal relationship between scalp fast (40-150Hz) oscillations (FOs) and slow waves in the ictal electroencephalograms (EEGs) of ESs.
In 11 infants with WS, ictal FOs were detected in a bipolar montage based on spectral and waveform criteria. Their temporal distribution was analyzed in terms of the positive peaks (trough point, T) of identical EEG data in a referential montage. Among six EEG data sections defined according to T, the number of FOs, peak power values, and peak frequencies were compared.
We identified a total of 1014 FOs (946 gamma and 68 ripple oscillations), which clustered closely at T. The number of gamma oscillations in the 1s epoch including T was significantly higher than those in the prior and subsequent phases. Peak power values and frequencies tended to be higher in these positive phase sections.
The temporal association of FO clustering and positive slow waves in the ictal EEGs of ES indicated that active neuronal firing related to FOs underlies the generation of ESs and their ictal slow waves.
为阐明韦斯特综合征中癫痫性痉挛（ESs）的发生机制，我们研究了ESs发作期脑电图（EEGs）中头皮快波（40 - 150Hz）振荡（FOs）与慢波之间的时间关系。
对11例韦斯特综合征婴儿，基于频谱和波形标准在双极导联中检测发作期FOs。根据参考导联中相同EEG数据的正峰（波谷点，T）分析其时间分布。在根据T定义的6个EEG数据段中，比较FOs的数量、峰值功率值和峰值频率。
我们共识别出1014个FOs（946个伽马振荡和68个涟漪振荡），它们在T处紧密聚集。包括T的1秒时段内伽马振荡的数量显著高于之前和之后的时段。这些正相段的峰值功率值和频率往往更高。
ESs发作期EEGs中FO聚集与正性慢波的时间关联表明，与FOs相关的活跃神经元放电是ESs及其发作期慢波产生的基础。
