Brans Y W, Andrew D S, Dutton E B, Schwartz C A, Carey K D
Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan.
Pediatr Res. 1989 Apr;25(4):377-82. doi: 10.1203/00006450-198904000-00014.
Dilution kinetics of markers commonly used for estimation of body water content and distribution in perinatal medicine (p-aminohippurate, inulin, antipyrine, H218O, bromide, and T1824) were studied in pregnant and neonatal baboons. Amniotic fluid concentrations of p-aminohippurate and inulin decreased exponentially after intraamniotic injection of these markers; from 2-24 h after injection, concentrations decreased linearly on semilogarithmic plot (r = 0.96-1.00). Plasma concentrations of antipyrine decreased exponentially during the first 60 min after intravenous injection, then linearly from 1-5 h (r = 0.92-0.90). Plasma concentrations of 18O decreased linearly from 1-6 h after injection in three or four cases (r = 0.94-0.99). Plasma concentrations of bromide decreased during the first 2 h after injection, then stabilized for at least 3 h. Plasma concentrations of T1824 decreased linearly from 10-60 min after intravenous injection (r = 0.97-1.00). Then the decline became exponential until 5 h. These data allow us to make specific recommendations regarding the optimal time and method of amniotic fluid and blood sampling during body water studies.
在怀孕和新生狒狒中研究了围产期医学中常用于估计身体水分含量和分布的标志物（对氨基马尿酸、菊粉、安替比林、H₂¹⁸O、溴化物和T₁₈₂₄）的稀释动力学。羊膜腔内注射这些标志物后，羊水中对氨基马尿酸和菊粉的浓度呈指数下降；注射后2至24小时，在半对数图上浓度呈线性下降（r = 0.96 - 1.00）。静脉注射后最初60分钟内安替比林的血浆浓度呈指数下降，然后在1至5小时呈线性下降（r = 0.92 - 0.90）。在三或四个病例中，注射后1至6小时¹⁸O的血浆浓度呈线性下降（r = 0.94 - 0.99）。注射后最初2小时内溴化物的血浆浓度下降，然后稳定至少3小时。静脉注射后10至60分钟T₁₈₂₄的血浆浓度呈线性下降（r = 0.97 - 1.00）。然后下降变为指数形式直至5小时。这些数据使我们能够就身体水分研究期间羊水和血液采样的最佳时间和方法提出具体建议。
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