Brans Y W, Kazzi N J, Andrew D S, Schwartz C A, Carey K D
Neonatal Research Laboratory, C.S. Mott Center for Human Growth and Development, Detroit, Mich.
Biol Neonate. 1990;58(3):137-44. doi: 10.1159/000243253.
Total body water was estimated simultaneously by dilution of antipyrine (antipyrine space; APS) and H2(18)O (18O-space; 18OS) in 5 baboon neonates and 2 two-month-old lambs (total of 14 studies). Calculations of 18OS were made either from a single plasma delta 18O measured 4 h after injection of the marker (18OS4) or by extrapolation to time zero of several plasma delta 18O obtained at precisely timed interval (18OS0). Mean (+/- SD) 18OS4 was on the average 23% lower than mean 18OS0 (796 +/- 70 ml/kg vs. 650 +/- 67 ml/kg, p less than 0.001). Mean APS was not statistically different from mean 18OS0 (664 +/- 127 ml/kg vs. 658 +/- 57 ml/kg), but APS ranged from 41% lower to 30% higher than 18OS0. These data and information from the literature suggest that antipyrine is of doubtful reliability and should be abandoned as a marker for total body water.
通过对5只新生狒狒和2只两个月大的羔羊（共进行了14项研究）进行安替比林稀释（安替比林空间；APS）和H2(18)O（18O空间；18OS）来同时估计总体水含量。18OS的计算要么基于注射标记物后4小时测得的单个血浆δ18O（18OS4），要么通过对在精确时间间隔获得的多个血浆δ18O外推至时间零点来进行（18OS0）。平均（±标准差）18OS4平均比平均18OS0低23%（分别为796±70 ml/kg和650±67 ml/kg，p<0.001）。平均APS与平均18OS0无统计学差异（分别为664±127 ml/kg和658±57 ml/kg），但APS比18OS0低41%至高30%。这些数据以及文献中的信息表明，安替比林的可靠性存疑，应摒弃其作为总体水含量标记物的用途。
