[肌酸代谢物的化学交换饱和转移成像：一项3.0T磁共振成像初步研究]
[Chemical Exchange Saturation Transfer Imaging of Creatine Metabolites: a 3.0 T MRI Pilot].
作者信息
Guo Ying-kun, Li Zhen-lin, Rong Yu, Xia Chun-chao, Zhang Li-zhi, Peng Wan-ling, Liu Xi, Xu Hua-yan, Zhang Ti-jiang, Zuo Pan-li, Schmitt Benjamin
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Mar;47(2):257-61.
OBJECTIVE
To determine the feasibility of using chemical exchange saturation transfer (CEST) imaging to measure creatine (Cr) metabolites with 3.0 T MR.
METHODS
Phantoms containing different concentrations of Cr under various pH conditions were studied with CEST sequence on 3.0 T MR imaging. CEST effect and Z spectra were analyzed.
RESULTS
Cr exhibited significant CEST effect (± 1.8 ppm, F = 99.08, P < 0.001) on 3.0 T MR imaging, and positive correlation was found between the signal intensity and concentration of Cr (r = 0.963, P < 0.001). The CEST effect showed pH dependency of Cr (r = 0.41, P = 0.035).
CONCLUSION
Creatine CEST imaging can be performed on 3.0 T MR imaging. Creatine concentrations and pH influence CEST effect.
目的
确定在3.0 T磁共振成像（MR）中使用化学交换饱和转移（CEST）成像测量肌酸（Cr）代谢物的可行性。
方法
在3.0 T MR成像上，使用CEST序列研究在各种pH条件下含有不同浓度Cr的体模。分析CEST效应和Z谱。
结果
在3.0 T MR成像上，Cr表现出显著的CEST效应（±1.8 ppm，F = 99.08，P < 0.001），并且发现信号强度与Cr浓度之间呈正相关（r = 0.963，P < 0.001）。CEST效应显示出Cr的pH依赖性（r = 0.41，P = 0.035）。
结论
肌酸CEST成像可在3.0 T MR成像上进行。肌酸浓度和pH会影响CEST效应。
Zotero 插件