Kyroudis A, Markantonis S L, Beckett A H
Department of Pharmacy, University of Athens, Greece.
Pharm Weekbl Sci. 1989 Apr 28;11(2):44-9. doi: 10.1007/BF01962974.
The effect of food on the movement of pellets in the gastro-intestinal tract was investigated in seven volunteers, either by means of X-rays taken after oral administration of barium sulfate pellets or by means of saliva concentration profiles of lithium obtained after oral administration of lithium sulfate controlled-release pellets. The X-ray studies showed that food had an effect on the time required for the pellets to leave the stomach and on their degree of dispersion in the small intestine, but not on other parameters. The studies with the lithium sulfate controlled-release pellets showed that food had a significant effect only in one in three subjects.
通过对7名志愿者进行研究，考察食物对胃肠道中药丸移动的影响。研究方法一是口服硫酸钡药丸后进行X光检查，二是口服硫酸锂控释药丸后检测唾液中锂的浓度变化。X光研究表明，食物对药丸离开胃部所需时间以及在小肠中的分散程度有影响，但对其他参数无影响。硫酸锂控释药丸的研究表明，食物仅对三分之一的受试者有显著影响。
