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A combination of dexamethasone and anti-IL-17A treatment can alleviate diesel exhaust particle-induced steroid insensitive asthma.

作者信息

Brandt Eric B, Khurana Hershey Gurjit K

机构信息

Division of Asthma Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Division of Asthma Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

出版信息

J Allergy Clin Immunol. 2016 Sep;138(3):924-928.e2. doi: 10.1016/j.jaci.2016.03.037. Epub 2016 May 5.

DOI:10.1016/j.jaci.2016.03.037
PMID:27264458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5014632/
Abstract
摘要

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本文引用的文献

1
Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility.接触过敏原和柴油废气颗粒会增强继发性过敏原特异性记忆反应，增加哮喘易感性。
J Allergy Clin Immunol. 2015 Aug;136(2):295-303.e7. doi: 10.1016/j.jaci.2014.11.043. Epub 2015 Mar 4.
2
IL-17 in severe asthma. Where do we stand?白细胞介素-17 在重症哮喘中的作用。我们处于什么位置？
Am J Respir Crit Care Med. 2014 Nov 15;190(10):1094-101. doi: 10.1164/rccm.201405-0859PP.
3
Increased frequency of dual-positive TH2/TH17 cells in bronchoalveolar lavage fluid characterizes a population of patients with severe asthma.支气管肺泡灌洗液中双阳性TH2/TH17细胞频率增加是重度哮喘患者群体的一个特征。
J Allergy Clin Immunol. 2014 Nov;134(5):1175-1186.e7. doi: 10.1016/j.jaci.2014.05.038. Epub 2014 Jul 18.
4
Aligning mouse models of asthma to human endotypes of disease.使哮喘小鼠模型与人类疾病内型相匹配。
Respirology. 2014 Aug;19(6):823-33. doi: 10.1111/resp.12315. Epub 2014 May 9.
5
Severe asthma: an expanding and mounting clinical challenge.严重哮喘：不断扩大和加剧的临床挑战。
J Allergy Clin Immunol Pract. 2013 Mar;1(2):110-21; quiz 122. doi: 10.1016/j.jaip.2013.01.005. Epub 2013 Feb 26.
6
Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma.随机、双盲、安慰剂对照研究布罗达umab（一种人抗 IL-17 受体单克隆抗体）在中重度哮喘中的应用。
Am J Respir Crit Care Med. 2013 Dec 1;188(11):1294-302. doi: 10.1164/rccm.201212-2318OC.
7
Diesel exhaust particle induction of IL-17A contributes to severe asthma.柴油机废气颗粒诱导白细胞介素-17A 导致严重哮喘。
J Allergy Clin Immunol. 2013 Nov;132(5):1194-1204.e2. doi: 10.1016/j.jaci.2013.06.048. Epub 2013 Sep 20.
8
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.辅助性T细胞17（TH17）介导小鼠体内对类固醇耐药的气道炎症和气道高反应性。
J Immunol. 2008 Sep 15;181(6):4089-97. doi: 10.4049/jimmunol.181.6.4089.