Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
Org Lett. 2016 Jun 17;18(12):2994-7. doi: 10.1021/acs.orglett.6b01357. Epub 2016 Jun 6.
The first cross-coupling of secondary alkyl β-trifluoroboratoketones and -esters has been achieved through application of photoredox/nickel dual catalysis. Although the related β-trifluoroboratoamides have been effectively cross-coupled via Pd-catalysis, the corresponding ketones and esters had proven recalcitrant prior to this report. Reactions occur under mild conditions, and a variety of functional groups and sterically and electronically diverse reaction partners are tolerated.
通过光氧化还原/镍双催化作用，首次实现了仲烷基 β-三氟硼酸盐酮和酯的交叉偶联。尽管相关的 β-三氟硼酸盐酰胺已通过 Pd 催化有效地进行了交叉偶联，但在此之前，相应的酮和酯一直被证明难以反应。反应在温和的条件下进行，各种官能团和空间位阻和电子多样性的反应伙伴都能耐受。
