Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
Acta Biomater. 2016 Sep 1;41:312-9. doi: 10.1016/j.actbio.2016.06.005. Epub 2016 Jun 3.
The applications of polymer microneedles (MNs) into human skin emerged as an alternative of the conventional hypodermic needles. However, dissolving MNs require many minutes to be dissolved in the skin and typically have difficulty being fully inserted into the skin, which may lead to the low drug delivery efficiency. To address these issues, we introduce rapidly separating MNs that can rapidly deliver drugs into the skin in a minimally invasive way. For the rapidly separating MNs, drug loaded dissolving MNs are mounted on the top of solid MNs, which are made of biodegradable polylactic acid which eliminate the biohazardous waste. These MNs have sufficient mechanical strength to be inserted into the skin with the drug loaded tips fully embedded for subsequent dissolution. Compared with the traditional MNs, rapidly separating MNs achieve over 90% of drug delivery efficiency in 30s while the traditional MNs needs 2min to achieve the same efficiency. With the in vivo test in mice, the micro-holes caused by rapidly separating MNs can heal in 1h, indicating that the rapidly separating MNs are safe for future applications. These results indicate that the design of rapidly separating dissolvable MNs can offer a quick, high efficient, convenient, safe and potentially self-administered method of drug delivery.
Polymer microneedles offer an attractive, painless and minimally invasive approach for transdermal drug delivery. However, dissolving microneedles require many minutes to be dissolved in the skin and typically have difficulty being fully inserted into the skin due to the skin deformation, which may lead to the low drug delivery efficiency. In this work we proposed rapidly separating microneedles which can deliver over 90% of drug into the skin in 30s. The in vitro and in vivo results indicate that the new design of these microneedles can offer a quick, high efficient, convenient and safe method for transdermal drug delivery.
聚合物微针（MNs）在人类皮肤上的应用是传统皮下注射针的替代方法。然而，溶解 MNs 需要几分钟才能在皮肤中溶解，而且通常很难完全插入皮肤，这可能导致药物输送效率低下。为了解决这些问题，我们引入了快速分离 MNs，可以以微创的方式将药物快速递送到皮肤中。对于快速分离 MNs，将负载药物的溶解 MNs 安装在由可生物降解的聚乳酸制成的实心 MNs 的顶部，这些实心 MNs 消除了生物危害废物。这些 MNs 具有足够的机械强度，可以插入皮肤，药物负载的尖端完全嵌入，随后溶解。与传统 MNs 相比，快速分离 MNs 在 30 秒内实现了超过 90%的药物输送效率，而传统 MNs 需要 2 分钟才能达到相同的效率。通过在小鼠中的体内测试，快速分离 MNs 引起的微孔在 1 小时内愈合，表明快速分离 MNs 对未来的应用是安全的。这些结果表明，快速分离可溶解 MNs 的设计可以提供一种快速、高效、方便、安全且具有潜在自我给药能力的药物输送方法。
聚合物微针为经皮药物输送提供了一种有吸引力、无痛和微创的方法。然而，溶解微针需要几分钟才能在皮肤中溶解，而且由于皮肤变形，通常很难完全插入皮肤，这可能导致药物输送效率低下。在这项工作中，我们提出了快速分离微针，可以在 30 秒内将超过 90%的药物递送到皮肤中。体外和体内结果表明，这些微针的新设计可以为经皮药物输送提供一种快速、高效、方便和安全的方法。
