CEITEC-Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; SCITEG, a.s., Brno, Czech Republic; National Research Centre, Textile Research Division, Department of Pre-treatment and Finishing of Cellulosic Fibers, Dokki, Cairo, Egypt.
CEITEC-Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; SCITEG, a.s., Brno, Czech Republic; Faculty of Chemistry, Institute of Materials Chemistry, Brno University of Technology, Brno, Czech Republic.
Int J Pharm. 2016 Aug 20;510(1):86-99. doi: 10.1016/j.ijpharm.2016.06.003. Epub 2016 Jun 2.
Chitin/chitosan-glucan complex (ChCsGC) was isolated from Schizophyllum commune (S. commune) and dissolved for the first time in precooled (-15°C) 8wt.% urea/6wt.% NaOH aqueous solution. Novel nonwoven microfiber mats were fabricated by wet-dry-spinning technique and evaluated the mechanical of fabrics mats and surface morphology. Isolated and nonwoven mat were characterized employing FTIR-ATR, Optical microscope, TGA, DSC, H/C NMR, SEM and XRD techniques. According to the physical/chemical characterization measurements we can assumed that, the net and the novel dressing mats have the same chemical structure with slightly changes in the thermal stability for the dressing mats.The biological activity of the nonwoven ChCsGC fabric was tested against different types of bacteria exhibiting excellent antibacterial activity. Cell viability of the plain complex and nonwovens mats were evaluated utilizing mouse fibroblast cell line varying concentrations and treatment time. ChCsGC did not show any cytotoxicity against mouse fibroblast cells and the cell-fabrics interaction was also investigated using fluorescence microscope. The novel ChCsGC nonwovens exhibited excellent surgical wound healing ability when tested using rat models.
几丁质/壳聚糖-葡聚糖复合物（ChCsGC）从裂褶菌（S. commune）中分离出来，并首次在预冷（-15°C）8wt.%尿素/6wt.%氢氧化钠水溶液中溶解。通过干湿纺丝技术制备了新型无纺微纤维垫，并评估了织物垫的机械性能和表面形貌。采用 FTIR-ATR、光学显微镜、TGA、DSC、H/C NMR、SEM 和 XRD 技术对分离物和无纺垫进行了表征。根据物理/化学特性测量，我们可以假设，新型非织造 ChCsGC 敷料垫与传统敷料垫具有相同的化学结构，但热稳定性略有变化。非织造 ChCsGC 织物的抗菌活性通过对不同类型的细菌进行测试，表现出优异的抗菌活性。利用不同浓度和处理时间的小鼠成纤维细胞系评估了普通复合物和无纺垫的细胞活力。ChCsGC 对小鼠成纤维细胞没有任何细胞毒性，并且还使用荧光显微镜研究了细胞-织物相互作用。新型 ChCsGC 无纺垫在大鼠模型中测试时表现出优异的手术伤口愈合能力。
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