孕期百日咳疫苗接种：婴儿体内抗体的持久性。
Pertussis vaccination during pregnancy: Antibody persistence in infants.
作者信息
Vilajeliu Alba, Ferrer Laia, Munrós Jordina, Goncé Anna, López Marta, Costa Josep, Bayas José M
机构信息
Department of Preventive Medicine and Epidemiology, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain; ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
Department of Maternal-Fetal Medicine, BCNatal - Barcelona Center of Maternal-Fetal and Neonatal Medicine, Hospital Clínic and Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain.
出版信息
Vaccine. 2016 Jul 19;34(33):3719-22. doi: 10.1016/j.vaccine.2016.05.051. Epub 2016 Jun 11.
Maternal pertussis vaccination is associated with higher levels of pertussis antibodies at birth. We assessed the persistence of pertussis antibodies until primary vaccination in infants whose mothers received Tdap (tetanus, diphtheria, acellular pertussis) vaccine during pregnancy. Infants were born at the Hospital Clinic of Barcelona (Spain) in November 2014. Anti-PT IgG was determined by ELISA at delivery, between the first and second month of life, and estimated at 2months of age. The study included 37 infants whose mothers received Tdap between 21 and 38weeks of gestation. Infants presented a decline in GMC of anti-PT IgG between peripartum and follow-up levels, 52.7 (95% CI 34.7-80.2) versus 7.5 (95% CI 4.2-13.3) at 2months of age (p<0.001). The median half-life of maternal antibodies was 47days. More than half (51.4%) the infants presented detectable anti-PT IgG before the start of primary infant vaccination.
母亲接种百日咳疫苗与婴儿出生时较高水平的百日咳抗体有关。我们评估了母亲在孕期接种破伤风、白喉、无细胞百日咳（Tdap）疫苗的婴儿中，百日咳抗体在初次疫苗接种前的持续情况。婴儿于2014年11月在西班牙巴塞罗那医院诊所出生。通过酶联免疫吸附测定法（ELISA）在分娩时、出生后第一个月至第二个月期间以及在2个月大时测定抗百日咳毒素（PT）IgG。该研究纳入了37名母亲在妊娠21至38周期间接种Tdap的婴儿。婴儿出生时及随访时抗PT IgG的几何平均浓度（GMC）出现下降，在2个月大时分别为52.7（95%可信区间34.7 - 80.2）和7.5（95%可信区间4.2 - 13.3）（p<0.001）。母亲抗体的中位半衰期为47天。超过一半（51.4%）的婴儿在开始婴儿初次疫苗接种前呈现可检测到的抗PT IgG。
Zotero 插件