46,XX/47,XX,+9/47,XX,+?mar嵌合体存在于同一羊水样本中，产后其中一条细胞系明显丢失。

Mosaicism of 46,XX/47,XX,+9/47,XX,+?mar in the same amniotic fluid with apparent loss of one cell line after delivery.

作者信息

Herens C, Pierquin G, Verloes A, Schaaps J P, Frederic J

机构信息

Human Genetic Department, Liège State University, Belgium.

出版信息

Prenat Diagn. 1989 May;9(5):373-5. doi: 10.1002/pd.1970090513.

DOI:10.1002/pd.1970090513

PMID:2726702

Abstract

A 46,XX;47,XX,+9;47,XX,+?mar karyotype was detected in an amniotic fluid cell culture and confirmed in a subsequent fetal blood sample from a 40-year-old woman. After termination of the pregnancy, none of the 186 mitoses obtained from a second blood sample was trisomic for chromosome 9 (p less than 0.001). Selection against cells containing trisomy 9 is postulated to explain the disappearance of the lymphocyte clone.

摘要

在一名40岁女性的羊水细胞培养物中检测到46,XX;47,XX,+9;47,XX,+?mar核型，并在随后的胎儿血样中得到证实。终止妊娠后，从第二份血样中获得的186个有丝分裂细胞中没有一个9号染色体三体（p<0.001）。推测对含有9号染色体三体的细胞的选择可以解释淋巴细胞克隆的消失。