确定非小细胞肺癌患者立体定向体部放射治疗计划靶区的最佳剂量处方

Determining the Optimal Dose Prescription for the Planning Target Volume with Stereotactic Body Radiotherapy for Non- Small Cell Lung Cancer Patients.

作者信息

Liu Xi-Jun, Lin Xiu-Tong, Yin Yong, Chen Jin-Hu, Xing Li-Gang, Yu Jin-Ming

机构信息

Departments of Radiation Oncology, Shandong University School of Medicine, Shandong Cancer Hospital and Institute, Jinan, Shandong, China E-mail :

出版信息

Asian Pac J Cancer Prev. 2016;17(5):2573-7.

PMID:27268632

Abstract

OBJECTIVE

The aim of this study was to determine a method of dose prescription that minimizes normal tissue irradiation outside the planning target volume (PTV) during stereotactic body radiotherapy (SBRT) for patients with non-small cell lung cancer.

METHODS

Previous research and patients with typical T1 lung tumors with peripheral lesions in the lung were selected for analysis. A PTV and several organs at risk (OARs) were constructed for the dose calculated; six treatment plans employing intensity modulated radiotherapy (IMRT) were produced, in which the dose was prescribed to encompass the PTV, with the prescription isodose level (PIL) set at 50, 60, 70, 80, 90 or 95% of the isocenter dose. Additionally, four OARs around the PTV were constructed to evaluate the dose received in adjacent tissues.

RESULTS

The use of higher PILs for SBRT resulted in improved sparing of OARs, with the exception of the volume of lung treated with a lower dose.

CONCLUSIONS

The use of lower PILs is likely to create significant inhomogeneity of the dose delivered to the target, which may be beneficial for the control of tumors with poor conformity indices.

摘要

目的

本研究的目的是确定一种剂量处方方法，在非小细胞肺癌患者的立体定向体部放射治疗（SBRT）期间，使计划靶体积（PTV）外的正常组织受照剂量最小化。

方法

选取先前的研究以及患有典型T1期肺部肿瘤且肺部有周围病变的患者进行分析。构建PTV和几个危及器官（OARs）用于剂量计算；生成六个采用调强放射治疗（IMRT）的治疗计划，其中剂量处方以涵盖PTV，处方等剂量水平（PIL）设定为等中心剂量的50%、60%、70%、80%、90%或95%。此外，在PTV周围构建四个OARs以评估相邻组织所接受的剂量。