镍催化二氧化碳与惰性烷基氯的羧化反应。
Ni-Catalyzed Carboxylation of Unactivated Alkyl Chlorides with CO2.
机构信息
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology , Av. Països Catalans 16, 43007 Tarragona, Spain.
Catalan Institution for Research and Advanced Studies (ICREA) , Passeig Lluïs Companys, 23, 08010, Barcelona, Spain.
出版信息
J Am Chem Soc. 2016 Jun 22;138(24):7504-7. doi: 10.1021/jacs.6b04088. Epub 2016 Jun 14.
PMID:27269443
Abstract
A catalytic carboxylation of unactivated primary, secondary, and tertiary alkyl chlorides with CO2 at atmospheric pressure is described. This protocol represents the first intermolecular cross-electrophile coupling of unactivated alkyl chlorides, thus leading to new knowledge in the cross-coupling arena.
摘要
本文描述了在常压下二氧化碳与未活化的伯、仲和叔氯代烷烃的催化羧化反应。该方案代表了首例未活化的烷基氯的分子间交叉亲电试剂偶联，从而为交叉偶联领域提供了新的知识。
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