Noël M
Laboratoire Génétique, Neurogénétique et Comportment, U.R.A. 216 CNRS UER Biomédicale, Paris, France.
Physiol Behav. 1989 Jan;45(1):21-6. doi: 10.1016/0031-9384(89)90161-3.
Effects on sensorimotor development of four genes (at, Re, fz, and Wv) involved in coat color differences were investigated by employing four coisogenic strains of mice with the same genetic background C57BL/6JOrl (B6). Compared to wild-type B6, two mutations (fz and Wv) showed pleiotropic effects on development but the direction of these effects (delay or advance) differed in different tests. Body weight was decreased for each mutation. Heterozygosity vs. homozygosity at the W locus caused differences in crossed extensor, bar holding and female body weight. Epistatic effects between the at and Re genes were investigated by developing a double coisogenic strain, and were found for righting, hindpaw grasping, vibrissae placing responses and weight.
通过使用具有相同遗传背景C57BL/6JOrl（B6）的四种近交系小鼠，研究了参与毛色差异的四个基因（at、Re、fz和Wv）对感觉运动发育的影响。与野生型B6相比，两个突变（fz和Wv）对发育表现出多效性作用，但这些作用的方向（延迟或提前）在不同测试中有所不同。每个突变均导致体重下降。W位点的杂合性与纯合性导致交叉伸肌、握杆和雌性体重存在差异。通过培育双近交系小鼠研究了at和Re基因之间的上位效应，发现其对翻正、后爪抓握、触须放置反应和体重有影响。
