Ladjel-Mendil Amina, Martin-Eauclaire Marie-France, Laraba-Djebari Fatima
USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria.
CNRS UMR 7286 CRN2M, Institut Fédératif de Recherche Jean Roche, Faculté de Médecine Nord, Aix-Marseille University, Marseille, France.
J Biochem Mol Toxicol. 2016 Dec;30(12):580-587. doi: 10.1002/jbt.21824. Epub 2016 Jun 7.
Kaliotoxin (KTX), a specific blocker of potassium channels, exerts various toxic effects due to its action on the central nervous system. Its use in experimental model could help the understanding of the cellular and molecular mechanisms involved in the neuropathological processes related to potassium channel dysfunctions. In this study, the ability of KTX to stimulate neuro-immuno-endocrine axis was investigated. As results, the intracerebroventricular injection of KTX leads to severe structural-functional alterations of both hypothalamus and thyroid. These alterations were characterized by a massive release of hormones' markers of thyroid function associated with damaged tissue which was infiltrated by inflammatory cell and an imbalanced redox status. Taken together, these data highlight that KTX is able to modulate the neuro-endocrine response after binding to its targets leading to the hypothalamus and the thyroid stimulation, probably by inflammatory response activation and the installation of oxidative stress in these organs.
卡利毒素（KTX）是一种钾通道特异性阻滞剂，因其对中枢神经系统的作用而产生多种毒性作用。将其用于实验模型有助于理解与钾通道功能障碍相关的神经病理过程中涉及的细胞和分子机制。在本研究中，研究了KTX刺激神经-免疫-内分泌轴的能力。结果表明，脑室内注射KTX会导致下丘脑和甲状腺出现严重的结构-功能改变。这些改变的特征是甲状腺功能激素标志物大量释放，伴有受损组织，该组织被炎性细胞浸润且氧化还原状态失衡。综上所述，这些数据表明KTX在与其靶点结合后能够调节神经内分泌反应，导致下丘脑和甲状腺受到刺激，这可能是通过激活炎症反应以及在这些器官中引发氧化应激实现的。
