Megwalu Uchechukwu C, Panossian Haig
Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, U.S.A.
Department of Otolaryngology - Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, U.S.A.
Anticancer Res. 2016 Jun;36(6):2903-7.
To evaluate survival outcomes of radiotherapy versus surgical resection in the treatment of early stage laryngeal cancer.
Data was extracted from the Surveillance, Epidemiology, and End Results 18 Database. The cohort included 5,301 patients diagnosed with stages I and II laryngeal squamous cell carcinoma between 1992 and 2009, treated with either surgical therapy or radiotherapy.
Patients who received surgical therapy had better overall survival (OS) than patients who received radiation therapy (p<0.001). The difference in OS between treatment groups remained after stratification by stage (p<0.001 for Stage I; p=0.03 for Stage II) and subsite (p<0.001). On multivariable analysis, the radiotherapy group had worse OS (hazard ratio (HR)=1.29).
Patients with early-stage laryngeal cancer treated with surgical therapy have better survival outcomes than patients treated with non-surgical therapy.
评估放射治疗与手术切除治疗早期喉癌的生存结果。
数据取自监测、流行病学和最终结果18数据库。该队列包括1992年至2009年间诊断为I期和II期喉鳞状细胞癌的5301例患者，接受手术治疗或放射治疗。
接受手术治疗的患者总生存期（OS）优于接受放射治疗的患者（p<0.001）。按分期（I期p<0.001；II期p=0.03）和亚部位（p<0.001）分层后，治疗组之间的总生存期差异仍然存在。多变量分析显示，放射治疗组的总生存期较差（风险比（HR）=1.29）。
接受手术治疗的早期喉癌患者比接受非手术治疗的患者有更好的生存结果。
