晶状体佩戴者的睑缘和睑板腺特征及症状

Eyelid Margin and Meibomian Gland Characteristics and Symptoms in Lens Wearers.

作者信息

Cox Stephanie M, Berntsen David A, Chatterjee Neil, Hickson-Curran Sheila B, Jones Lyndon W, Moezzi Amir M, Morgan Philip B, Nichols Jason J

机构信息

*OD, FAAO †OD, PhD, FAAO ‡BSc, MSc, MCOptom §BSc, MCOptom, FAAO ∥PhD, FCOptom, FAAO **MSc, BOptom ††BSc, PhD, MCOptom, FAAO ‡‡OD, MPH, PhD, FAAO The University of Alabama at Birmingham, School of Optometry, Birmingham, Alabama (SMC, JJN); The Ocular Surface Institute, College of Optometry, University of Houston, Houston, Texas (DAB); Eurolens Research, Division of Pharmacy and Optometry, University of Manchester, Manchester, United Kingdom (NC, PBM); Johnson & Johnson Vision Care, Inc., Jacksonville, Florida (SBH-C); and Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, Ontario, Canada (LWJ, AMM).

出版信息

Optom Vis Sci. 2016 Aug;93(8):901-8. doi: 10.1097/OPX.0000000000000900.

DOI:10.1097/OPX.0000000000000900

PMID:27273272

Abstract

PURPOSE

To describe the lid margin characteristics of contact lens wearers and relate them to comfort during lens wear.

METHODS

Three study sites enrolled habitual contact lens wearers. Subjects completed the Comfort domain of the Contact Lens User Experience (CLUE) questionnaire, and each eye was graded for the presence of mucocutaneous junction (MCJ) displacement, lid margin irregularity, and lid margin vascularity. Examiners counted the number of meibomian gland (MG) orifices in the central centimeter of the lower eyelid and the number of those that showed pouting/plugging and vascular invasion. MG expressibility was graded according to the Shimazaki schema. Subjects were grouped based on presence/absence of each characteristic, total number of orifices (≥5 vs. <5), and expressibility (grade 0 vs. >0). Descriptive statistics are reported. A linear model was used to assess the fixed effect of each characteristic on combined CLUE score and each CLUE statement, if the effect on combined CLUE score showed p < 0.10.

RESULTS

The study included 203 subjects (67.5% female) with mean age (±SD) of 30.3 ± 9.6 years. The most commonly observed characteristics were orifice pouting/plugging, compromised MG expressibility, and lid margin vascularity (35.0, 30.3, and 20.4%, respectively). MCJ displacement and MG expressibility had an effect on the combined CLUE score such that individual CLUE statements were analyzed (p = 0.01 and p = 0.06, respectively). MCJ displacement had an effect on comfort upon insertion (p = 0.01), comfort after 5 minutes (p = 0.03), end-of-day comfort (p = 0.01), and ability to maintain ocular moisture (p = 0.030). MG expressibility had a significant effect on general comfort (p = 0.01), comfort throughout the day (p = 0.02), and the ability to maintain ocular moisture (p = 0.02).

CONCLUSIONS

MCJ displacement and MG expressibility have an effect on contact lens comfort.

摘要

目的

描述隐形眼镜佩戴者的睑缘特征，并将其与佩戴过程中的舒适度相关联。

方法

三个研究地点招募了习惯性隐形眼镜佩戴者。受试者完成了隐形眼镜用户体验（CLUE）问卷的舒适度领域部分，并且对每只眼睛的粘膜皮肤交界处（MCJ）移位、睑缘不规则和睑缘血管情况进行分级。检查者统计下睑中央1厘米范围内睑板腺（MG）开口的数量，以及出现撅嘴/堵塞和血管侵入的开口数量。根据岛崎分类法对MG的可挤压性进行分级。受试者根据每种特征的有无、开口总数（≥5个与<5个）以及可挤压性（0级与>0级）进行分组。报告描述性统计数据。如果对综合CLUE评分的影响显示p<0.10，则使用线性模型评估每种特征对综合CLUE评分和每条CLUE陈述的固定效应。

结果

该研究纳入了203名受试者（67.5%为女性），平均年龄（±标准差）为30.3±9.6岁。最常观察到的特征是开口撅嘴/堵塞、MG可挤压性受损和睑缘血管情况（分别为35.0%、30.3%和20.4%）。MCJ移位和MG可挤压性对综合CLUE评分有影响，因此对个体CLUE陈述进行了分析（分别为p=0.01和p=0.06）。MCJ移位对插入时的舒适度（p=0.01）、5分钟后的舒适度（p=0.03）、一天结束时的舒适度（p=0.01）以及保持眼内湿润的能力（p=0.030）有影响。MG可挤压性对总体舒适度（p=0.01）、全天舒适度（p=0.02）以及保持眼内湿润的能力（p=0.02）有显著影响。