Hata Toshiyuki, Kuno Atsushi, Dai Shu-Yan, Inubashiri Eisuke, Hanaoka Uiko, Kanenishi Kenji, Yamashiro Chizu, Tanaka Hirokazu, Yanagihara Toshihiro
Department of Perinatology and Gynecology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kagawa, 761-0793, Japan.
Department of Obstetrics and Gynecology, Suzuki Hospital, Toyota, Aichi, Japan.
J Med Ultrason (2001). 2007 Mar;34(1):17-21. doi: 10.1007/s10396-006-0122-y. Epub 2007 Mar 15.
The objective of this longitudinal study was to evaluate the growth of the fetal cerebellum in normal pregnancy by using three-dimensional ultrasound.
Three-dimensional sonographic examinations were performed for 13 appropriate-for-gestational-age fetuses. Fetal cerebellar volume was measured every 2 to 3 weeks after 20 weeks of gestational age until delivery. The common multiplanar technique was used to calculate the fetal cerebellar volume.
A curvilinear relationship was found between gestational age and cerebellar volume (R(2) = 78.6%, P < 0.0001), and normal ranges of cerebellar volume measurements for estimating the growth of the fetal cerebellum during normal pregnancy were generated. The data gathered in this study were fairly comparable with previous data obtained using three-dimensional ultrasound. However, the normal ranges of cerebellar volume that we determined were relatively wide throughout pregnancy.
Our findings suggest that a standard curve for fetal cerebellar volume using three-dimensional ultrasound can play a role in the evaluation of normal cerebellar growth in the fetus. However, we do cast doubt on the reliability and reproducibility of cerebellar volume measurement using three-dimensional ultrasound. Further studies involving a larger sample size and another technique (the rotational method with VOCAL) would be needed to confirm these findings.
这项纵向研究的目的是通过三维超声评估正常妊娠中胎儿小脑的生长情况。
对13例适于胎龄的胎儿进行三维超声检查。在孕20周后每2至3周测量一次胎儿小脑体积，直至分娩。采用常用的多平面技术计算胎儿小脑体积。
发现胎龄与小脑体积之间存在曲线关系（R² = 78.6%，P < 0.0001），并得出了正常妊娠期间估计胎儿小脑生长的小脑体积测量正常范围。本研究收集的数据与先前使用三维超声获得的数据相当。然而，我们确定的小脑体积正常范围在整个孕期相对较宽。
我们的研究结果表明，使用三维超声的胎儿小脑体积标准曲线可在评估胎儿正常小脑生长中发挥作用。然而，我们确实对使用三维超声测量小脑体积的可靠性和可重复性表示怀疑。需要进一步开展涉及更大样本量和另一种技术（VOCAL旋转法）的研究来证实这些发现。
