急性白血病中的快速细胞减灭。通过血细胞分离术治疗脑白细胞淤滞。

Rapid cytoreduction in acute leukemia. Management of cerebral leukostasis by cell pheresis.

作者信息

Eisenstaedt R S, Berkman E M

出版信息

Transfusion. 1978 Jan-Feb;18(1):113-5. doi: 10.1046/j.1537-2995.1978.18178118553.x.

DOI:10.1046/j.1537-2995.1978.18178118553.x

Abstract

A patient with acute myelogenous leukemia and symptoms of cerebral leukostasis failed to respond to initial chemotherapy. Reduction in blast count from 220,000/microliter to 40,000/microliter was accomplished over a five hour period by leukapheresis using an intermittent flow cell separator, and symptomatic improvement was dramatic. The technique is simple and rapidly effective and may prove a useful adjunct in the treatment of patients with acute leukemia and high blast counts.

摘要

一名患有急性髓性白血病且有脑白质沉积症状的患者对初始化疗无反应。通过使用间歇流动细胞分离器进行白细胞去除术，在五小时内将原始细胞计数从220,000/微升降至40,000/微升，症状改善显著。该技术简单且起效迅速，可能成为治疗急性白血病且原始细胞计数高的患者的有用辅助手段。