ω-3补充剂在双相I型障碍患者治疗中的作用
Effects of Omega-3 Supplement in the Treatment of Patients with Bipolar I Disorder.
作者信息
Shakeri Jalal, Khanegi Maryam, Golshani Sanobar, Farnia Vahid, Tatari Faeze, Alikhani Mostafa, Nooripour Roghih, Ghezelbash Mohammad Saeed
机构信息
Department of Psychiatry, Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Psychiatry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Int J Prev Med. 2016 May 19;7:77. doi: 10.4103/2008-7802.182734. eCollection 2016.
BACKGROUND
Fatty acids play various physiological roles in the organism; they are crucial for the structure of cell membranes, metabolic processes, transmission of nerve impulses and brain functions. In recent years, particular attention has been paid to the rich sources of omega-3 for the treatment of many diseases, especially mental illnesses. The present study aimed to investigate the effects of omega-3 supplement in the treatment of patients with bipolar I disorder (BID).
METHODS
In this double-blind clinical trial, 100 patients suffering from BIDs were randomly divided into two, i.e. control (n = 50) and experimental (n = 50) groups. In addition to the other standard treatments, 1000 mg of omega-3 supplement was given to the experimental group on daily basis for 3 months and placebo was given to the control group. The Young Mania Rating Scale was completed for both groups before and after the intervention. Afterward, data were analyzed using paired t-test, independent t-test, and Chi-square test.
RESULTS
Before intervention, mean severity of mania in the experimental group (23.50 ± 7.02) and control group (23.70 ± 8.09) was not significant (P ≤ 0.89). The difference after the intervention in the experimental group (10.64 ± 3.3) and control group (20.12 ± 6.78) was significant (P < 0.01). The mean intensity of mania before (23.50 ± 7.02) and after (10.64 ± 3.3) intervention reported to be significant at P < 0.05.
CONCLUSIONS
Since omega-3 supplement was effective for the treatment of BID, it is suggested to use omega-3 supplements as an adjuvant therapy along with the other pharmacotherapies.
背景
脂肪酸在机体中发挥着多种生理作用；它们对于细胞膜结构、代谢过程、神经冲动传递及脑功能至关重要。近年来，富含ω-3脂肪酸的来源在治疗多种疾病，尤其是精神疾病方面受到了特别关注。本研究旨在探讨补充ω-3脂肪酸对双相I型障碍（BID）患者的治疗效果。
方法
在这项双盲临床试验中，100例双相I型障碍患者被随机分为两组，即对照组（n = 50）和试验组（n = 50）。除其他标准治疗外，试验组每天给予1000mg ω-3补充剂，持续3个月，对照组给予安慰剂。干预前后两组均完成杨氏躁狂量表评定。之后，采用配对t检验、独立t检验和卡方检验进行数据分析。
结果
干预前，试验组（23.50±7.02）和对照组（23.70±8.09）的躁狂平均严重程度无显著差异（P≤0.89）。干预后试验组（10.64±3.3）和对照组（20.12±6.78）的差异有统计学意义（P<0.01）。干预前（23.50±7.02）和干预后（10.64±3.3）的躁狂平均强度在P<0.05时具有统计学意义。
结论
由于补充ω-3脂肪酸对双相I型障碍治疗有效，建议将ω-3补充剂作为辅助治疗与其他药物疗法联合使用。
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