Chauhan S S, Singh S K, Misra U K
Department of Biochemistry, V.P. Chest Institute, University of Delhi, India.
Toxicology. 1989 May 31;56(1):95-105. doi: 10.1016/0300-483x(89)90215-1.
The effect of fly ash inhalation on xenobiotic metabolizing enzymes and heme metabolism in lung and liver has been studied in rats. Fly ash inhalation induced pulmonary and hepatic cytochrome P-450 content, aryl hydrocarbon hydroxylase and glutathione S-transferase activity. Induction of cytochrome P-450 was accompanied by induction of delta-amino levulinic acid synthetase in lung and inhibition of heme oxygenase in both lung and liver. Fly ash inhalation induced those species of cytochrome P-450 which closely resembled cytochrome P-448 in spectral properties and electrophoretic mobility.
在大鼠中研究了吸入粉煤灰对肺和肝脏中异生物代谢酶及血红素代谢的影响。吸入粉煤灰可诱导肺和肝脏中的细胞色素P - 450含量、芳烃羟化酶和谷胱甘肽S - 转移酶活性。细胞色素P - 450的诱导伴随着肺中δ-氨基乙酰丙酸合成酶的诱导以及肺和肝脏中血红素加氧酶的抑制。吸入粉煤灰诱导了那些在光谱特性和电泳迁移率上与细胞色素P - 448非常相似的细胞色素P - 450种类。
