Vlodavskii E A
Urol Nefrol (Mosk). 1989 Mar-Apr(2):25-7.
The purpose of the study was to determine the value of macro- and microscopic signs of primary tumor that had the highest chance to contribute to metastatic growth in renal cancer patients within 3 years after nephrectomy. The study covered 92 cases of renal cancer, including 42 cases with, and 50 cases, without metastases by the time of surgery, autopsy or within 3 years after nephrectomy. Diagnostic coefficients were calculated for each sign by means of the consecutive Walde's analysis, and their respective values were estimated by Coulbaque's formula. The degree of malignancy was assessed on the basis of a combination of quantitative parameters of proliferative activity and cataplasia of the tumor. The degree of malignancy, tumor stage by the PTNM classification, size and growth pattern, renal vein involvement and the volume of necrotic foci were the most valuable predictors of metastatic growth.
本研究的目的是确定原发性肿瘤的宏观和微观体征的价值，这些体征最有可能促使肾癌患者在肾切除术后3年内发生转移生长。该研究涵盖了92例肾癌病例，其中42例在手术、尸检时或肾切除术后3年内出现转移，50例未出现转移。通过连续的瓦尔德分析计算每个体征的诊断系数，并根据库尔巴克公式估计其各自的值。根据肿瘤增殖活性和化生的定量参数组合评估恶性程度。恶性程度、PTNM分类的肿瘤分期、大小和生长模式、肾静脉受累情况以及坏死灶体积是转移生长最有价值的预测指标。
