Hanash K A
King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Urology. 1989 Jun;33(6):466-7. doi: 10.1016/0090-4295(89)90132-5.
Ketoconazole, an antifungal agent, has been recently used for the treatment of metastatic (Stage D) prostatic carcinoma. It acts by blocking the synthesis of androgens in the tests and adrenal glands. Its major side effects are gastrointestinal and hepatic. We describe a patient in whom severe mental disturbances developed following ketoconazole treatment. Symptoms improved after withdrawal of the drug.
酮康唑是一种抗真菌药物，最近已被用于治疗转移性（D期）前列腺癌。它通过阻断睾丸和肾上腺中雄激素的合成发挥作用。其主要副作用是胃肠道和肝脏方面的。我们描述了一名在接受酮康唑治疗后出现严重精神障碍的患者。停药后症状有所改善。
