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儿童白血病治疗的终止。对北欧国家160例病例的调查。

Cessation of therapy in childhood leukemia. A survey of 160 cases from the Nordic Countries.

作者信息

Moe P J

出版信息

Acta Paediatr Scand. 1978 Mar;67(2):145-9. doi: 10.1111/j.1651-2227.1978.tb16294.x.

DOI:10.1111/j.1651-2227.1978.tb16294.x
PMID:272817
Abstract

A survey is presented of 160 children from the Nordic countries who had their antileukemic therapy discontinued prior to November 1976. Twenty-seven of the 160 cases (17%) had suffered a relapse before May, 1977. Sixty-nine cases had their therapy stopped in the first ten months of 1976. All cases have been reported as acute lymphocytic leukemia. Different types of therapy schedules have been used. Thirty-five cases in sustained remission for more than 3 years without cessation of therapy are also included in the report, seventeen of whom had relapsed while still on therapy. Central nervous system or testicular relapse occurred in 21 of the total 44 cases who relapsed after three or more years of continuous remission, and whether they were on therapy or not.

摘要

本文对1976年11月前停止抗白血病治疗的160名北欧儿童进行了调查。160例中有27例(17%)在1977年5月前复发。69例在1976年的前10个月停止治疗。所有病例均报告为急性淋巴细胞白血病。采用了不同类型的治疗方案。报告中还包括35例持续缓解超过3年且未停止治疗的病例,其中17例在仍接受治疗时复发。在44例持续缓解三年或更长时间后复发的病例中,无论是否接受治疗,21例发生了中枢神经系统或睾丸复发。

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