Hast R
Acta Med Scand. 1978;203(1-2):93-4. doi: 10.1111/j.0954-6820.1978.tb14837.x.
In four patients with chronic myelocytic leukemia, a solitary rise in serum alkaline phosphatase (S-ALP) was noted 2--12 months prior to death. All patients had received busulphan (Myleran) therapy for longer than 12 months (total dosage 1.0--2.4 g). It is suggested that the increase in S-alp was due to a cholestatic liver damage, possible secondary to the busulphan treatment.
在4例慢性粒细胞白血病患者中，发现血清碱性磷酸酶（S-ALP）在死亡前2至12个月出现单独升高。所有患者接受白消安（马利兰）治疗均超过12个月（总剂量1.0至2.4克）。提示S-ALP升高是由于胆汁淤积性肝损伤，可能继发于白消安治疗。
