Walker W R, Reeves R
Agents Actions Suppl. 1977(1):109-17.
In the introduction the chemistry of some bivalent copper complexes of aspirin and salicylate is briefly reviewed and the biological importance of mixed-ligand complexes of bivalent copper is illustrated. The nature of hydroxy-bridged copper (II) complexes and their possible role in the physiological activity of histamine is also discussed. Several neutral, insoluble copper (II) complexes of the type (Chelate-Cu-salicylate) 0-lambda H2O where chelate = 1, 10-phenanthroline (phen), chi = 1; 2,2'-bipyridyl (bipy), chi = 2; histamine (Ha), chi = 1; and where salicylate (sal) = dianion of salicylic acid have been prepared for the first time. They have been characterised by physico-chemical methods and the role of binuclearhydroxy-bridged copper (II) complex ions in their formation is demonstrated. Such complexes may be relevant to the pharmacological action of histamine and of the salicylates, the copper complexes of which are potential anti-inflammatory drugs. Results of some in vivo experiments that have been carried out with mice are also presented.
在引言部分，简要回顾了阿司匹林和水杨酸盐的一些二价铜配合物的化学性质，并阐述了二价铜混合配体配合物的生物学重要性。还讨论了羟基桥联铜（II）配合物的性质及其在组胺生理活性中的可能作用。首次制备了几种类型为（螯合物 - Cu - 水杨酸盐）0 - λH₂O的中性、不溶性铜（II）配合物，其中螯合物 = 1,10 - 菲咯啉（phen），χ = 1；2,2'-联吡啶（bipy），χ = 2；组胺（Ha），χ = 1；水杨酸盐（sal） = 水杨酸二价阴离子。它们已通过物理化学方法进行了表征，并证明了双核羟基桥联铜（II）络合离子在其形成中的作用。此类配合物可能与组胺和水杨酸盐的药理作用相关，水杨酸盐的铜配合物是潜在的抗炎药物。还展示了一些用小鼠进行的体内实验结果。
